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M9490058.TXT
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1994-09-03
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Document 0058
DOCN M9490058
TI The effect of nebulised pentamidine on the concentration of intra-oral
Candida albicans in HIV-infected patients.
DT 9411
AU Nolan A; Lamey PJ; MacFarlane TW; Aitchison TC; Shaw J; Sirel JY;
Department of Oral Medicine, Eastman Dental Hospital, London.
SO J Med Microbiol. 1994 Aug;41(2):95-7. Unique Identifier : AIDSLINE
MED/94322377
AB This prospective study investigated whether oral candidal carriage in
HIV-infected patients was altered by pentamidine therapy. Repeated oral
rinses were taken from 56 HIV-positive patients over a 2-year period.
Oral candidal carriage was investigated in two groups of patients, one
receiving prophylactic pentamidine therapy and the other not receiving
regular prophylaxis. Patients receiving pentamidine had lower
concentrations of Candida albicans intra-orally than patients who did
not receive it. Furthermore, patients who received pentamidine at one
stage of the study, but not another, also had lower concentrations of C.
albicans intra-orally when receiving pentamidine. These findings
indicate that pentamidine is useful as a local agent for prophylaxis
against intra-oral candidosis in HIV-infected patients.
DE Administration, Inhalation Adult Aerosols Candida albicans/*DRUG
EFFECTS/ISOLATION & PURIF Candidiasis, Oral/*PREVENTION & CONTROL
Carrier State/*PREVENTION & CONTROL Female Follow-Up Studies Human
HIV Infections/*COMPLICATIONS Male Middle Age Mouth
Mucosa/MICROBIOLOGY Pentamidine/ADMINISTRATION &
DOSAGE/PHARMACOLOGY/*THERAPEUTIC USE Prospective Studies CLINICAL
TRIAL JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).